Ignatieva E.V., Ananko E.A., Kel O.V., Podkolodnaya O.A., Merkulova T.I., Stepanenko I.L., Busygina T.V., Kozlova O.N., Kolpakov F.A., Lavryushev S.V., Grigorovich D.A., Podkolodny N.L., Frolov A.S., Kel A.E., Kolchanov N.A.
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, 630090, Novosibirsk, Russia; FAX: 7-(3832)331278; E-mail: eignat@bionet.nsc.ru
Understanding of the principles that underlie the complex dynamic biomolecular
networks is an important goal of biocomputing science. An essential step
in solving this problem is compiling and cataloging numerous data on the
gene expression and transcription regulation. The group of genes involved
in the lipid metabolism may serve as an interesting example of functional
gene systems. The proteins encoded by these genes participate in a variety
of processes essential for normal lipid homeostasis. This group contains
genes of transport proteins, enzymes of both lipid biosynthesis and degradation,
cell surface receptors, hormones and transcription factors. To study the
main principles of organization of this functional gene system, we developed
the Lipid Metabolism Transcription Regulatory Regions Database (LM-TRRD)
[1], which is available via the Internet at http://wwwicg.bionet.nsc.ru/trrd/34/lipmet.htm.
It is a part of a global information system on Transcription Regulatory
Regions of Eukaryotic Genes (TRRD) available at http://wwwicg.bionet.nsc.ru/trrd/34/
[2]. LM-TRRD contains data on over 50 vertebrate genes. Analysis of the
information contained in the LM-TRRD revealed that the following transcription
factors play key roles in the regulation of the genes from the LM-TRRD
database: SREBP, PPAR, RAR, RXR, HNF-4, COUP-TF, and SF-1.